PREVALENCE OF GASTROESOPHAGEAL REFLUX DISEASE AMONG DIABETIC PATIENTS: A SYSTEMATIC REVIEW
Abstract
Background: Gastroesophageal reflux disease (GERD) is a common comorbidity among diabetic patients, but its prevalence and associated risk factors remain unclear. This systematic review aimed to determine the prevalence of GERD among diabetic patients and explore potential risk factors associated with this comorbidity.
Methods: A comprehensive search of PubMed, MEDLINE, Embase, Scopus, and Cochrane Library was conducted to identify relevant studies. Observational studies (cohort studies, case-control studies), cross-sectional studies, and systematic reviews/meta-analyses reporting on the prevalence or risk factors of GERD among diabetic patients were included. Data extraction and synthesis were conducted following predefined protocols.
Results: A total of 956 studies were initially identified, with 14 full-text articles reviewed. Eight studies met the inclusion criteria and were included in the systematic review. The prevalence of GERD among diabetic patients ranged from 16% to 48.7% across studies, with considerable variability observed. Some studies found significant associations between GERD and demographic factors such as gender and age, while others did not. Inconsistencies were also observed in the association of GERD with diabetic complications, duration of diabetes, and metabolic factors. Variations were noted in the impact of peripheral neuropathy on GERD-related complications, highlighting the complexity of this relationship.
Conclusion: This systematic review provides insights into the prevalence and risk factors of GERD among diabetic patients. The findings underscore the need for further research to elucidate the underlying mechanisms and risk factors associated with this comorbidity. Understanding the relationship between GERD and diabetes mellitus is crucial for effective management and prevention strategies. Further studies with standardized methodologies and larger sample sizes are warranted to confirm these findings and guide clinical practice.
