NEONATAL THROMBOCYTOPENIA AND SEPSIS: DIAGNOSTIC CHALLENGES IN THE FIRST WEEK OF LIFE

Abstract

Neonatal thrombocytopenia and sepsis are significant clinical concerns in the first week of life, often presenting diagnostic challenges due to their overlapping symptoms and the immature physiological systems of newborns. This article explores the complexities of diagnosing and managing these conditions, highlighting the critical role of early detection and timely intervention. The physiological differences in platelet function between neonates and older individuals contribute to the difficulty in managing thrombocytopenia, which can be exacerbated by sepsis. The study reviews recent advancements in diagnostic techniques, including the use of biomarkers such as C-reactive protein, procalcitonin, and interleukins, which improve the sensitivity and specificity of diagnosing neonatal sepsis. Additionally, clinical cases are presented to illustrate real-world challenges, providing insight into the diagnostic process and the management strategies employed in neonatal intensive care units. The article emphasizes the importance of multidisciplinary collaboration in the treatment of neonates with these conditions and underscores the need for further research to refine diagnostic criteria and improve patient outcomes. This comprehensive review offers valuable guidance for healthcare professionals in diagnosing, treating, and managing neonatal thrombocytopenia and sepsis, particularly in resource-limited settings.