NARINGENIN’S JOURNEY IN MODERN MEDICINE: FROM CITRUS FLAVONOID TO VARIOUS ANTI-CANCER ACTIVITIES
Keywords:
Naringenin, Citrus flavonoid, Anti-cancer, Apoptosis, Cell cycle arrest, Signaling pathway.Abstract
Background: Naringenin, a bioactive flavonoid mainly present in citrus fruits, has attracted considerable interest because of its wide range of pharmacological benefits, such as antioxidant, anti-inflammatory, anti-cancer, cardioprotective and anti-diabetic effects. Despite its promising therapeutic potential, naringenin faces challenges related to its poor bioavailability and rapid metabolism.
Methods: Recent advancements in drug delivery systems, including nanoformulations and liposomes, aim to overcome these limitations and enhance its clinical efficacy. Preclinical studies have demonstrated its efficacy in various disease models, like cancer, cardiovascular (CV) diseases, diabetes, and neurodegenerative disorders.
Results: Naringenin has exposed efficacy in preclinical models for numerous diseases, highlighting its potential in disease treatment, particularly in cancer treatment. The advanced drug delivery systems help advance its clinical efficacy by increasing its bioavailability and stability.
Conclusion: This review attempts to bridge the gap between laboratory research and clinical application of naringenin’s anti-cancer effects by thoroughly analyzing existing knowledge and future potential.
